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Synapsin LPT White Paper


Synapsin LPT

Synapsin LPT™ by Mental Case is a groundbreaking advancement in cognitive enhancement. In this document, we delve into the science, research, and innovative technology behind Synapsin LPT, a nootropic formula designed to elevate mental clarity and cognitive performance in humans.  Discover the unique benefits of patent pending liposomal chewable tabs (lipotabs) and gain a deeper understanding of how Synapsin LPT can help unlock full mental and cognitive potential. Whether you’re a professional seeking peak productivity or someone committed to cognitive well-being, this white paper provides valuable insights into this cutting-edge brain enhancing nootropic.

Synapsin LPT is a unique, highly bioavailable, chewable liposomal tablet (lipotab LPT) using Rg3 ginsenoside from steamed Panax ginseng (C.A. Meyer) root.  Synapsin LPT is used to support improved energy, cognition, and focus.

Rg3 is a unique ginsenoside phytocompound from Panax ginseng that is about 0.1% of the steamed root – Synapsin LPT uses highly concentrated Rg3 at 85-90%.  Rg3 is an exciting new molecule from Panax ginseng, with scientific studies in humans reporting antiinflammatory/ antioxidant activity, metabolic support and neuroprotection for the brain.

Korean red ginseng

Supporting Research:
Rg3 from Korean red ginseng (Panax ginseng)

  • Ginsenoside Rg3 administration appeared to improve cognitive functions by significantly decreasing expression of pro-inflammatory mediators such as TNF-α, IL-1β, and COX-2 in the hippocampus.[i]
  • Rg3 also improves mitochondrial dysfunction, which improves cognitive impairment.[ii]
  • Laboratory studies report that Rg3 extracted from Panax ginseng is neuroprotective, helping to decrease microglia activation and neuroinflammatory processes.[iii],[iv],[v]
  • Antagonizes glutamate neurotoxicity by NMDA receptor inhibition.[vi][vii]
  • Support for opioid withdrawal and addiction recovery
  • Glutamate, the main “excitatory” neurochemical in the brain, plays a pivotal role in addiction, with the NMDA receptor a target of drugs of abuse, including opiates and cocaine[viii]
  • NMDA receptors are implicated in producing cognitive deficits seen in opiate abuse.
  • Rg3 is a novel Na+ channel inhibitor capable of acting on resting and open states of Na+ channels via interactions with the S4 voltage-sensor segment of domain II
  • Studies report Rg3 most effective ginsenoside at neuronal Na+ regulation[ix]
  • Rg3 is reported to have anti-inflammatory activity via COX-2 inhibition and reduction of inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokine expression, including TNF-alpha and IL-1B.[x]
  • Rg3 has been studied and reported effective (laboratory and human studies) in symptoms of Metabolic Syndrome:[xi]
    • Obesity – improves GLUT4 expression, PPAR-gamma expression and AMPK phosphorylation, decreases adipocyte differentiation and lipogenesis)
    • NAFLD (non-alcoholic fatty liver disease, decreases inflammation, supports ALT/AST levels, improves PPAR and AMPK gamma expression, decreases hepatic lipid levels and TNF-alpha)
    • Blood glucose/insulin support – decreases oxidative stress, AGE formation, increases insulin secretion and glucose tolerance, decreases lipid and blood glucose levels (fasting and post-prandial), improves PPAR-gamma, AMPK expression and body weight
    • Hypertension – decreases blood pressure, decreases blood vessel wall thickness, decreases renin and angiotensin-1 levels, improves blood vessel health

Why Lipotabs?

Liposomal LPT chewable tabs provide a safe and more efficient way for the body to absorb nutrients, peptides and other targeted therapeutic compounds. LPT does not have stability problems that plague the liposomal industry – LPT are proven stable.

Liquid liposomal products have inherent stability issues. Issues with Liquid Liposomes on the Market include:

  • Needs significant heat to produce – makes product unstable and decomposes active and inert ingredients in the product
  • Particles clump together to form larger and larger particle size
    • Liquid liposomes reported to grow from 100nm size to 3000nm over a 30-day period[xii]
    • Larger particle size means less bioavailable
    • Larger size also means increased potential for side-effects.

LPT particles don’t require heat for production and don’t “clump” like liquid liposomes over time

  • Means Greater Bioavailability
  • Greater Stability
  • Superior Product
  • Superior Results
  • No toxic excipients

Lipotabs are safe, chewable, oral liposomal tablets manufactured using patented, small molecule technology to improve bioavailability and biological effects.

[i] Lee B, et al. Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments by Anti-Inflammatory Activity in Rats. Biomol Ther (Seoul). 2013;21(5):L381-90.

[ii] Zhang Y, et al. Ginsenoside Rg3 Prevents Cognitive Impairment by Improving Mitochondrial Dysfunction in the Rat Model of Alzheimer’s Disease. J Agric Food Chem. 2019;67(36):10048-58.

[iii] Joo SS, Yoo YM, Ahn BW, Nam SY, Kim YB, Hwang KW, Lee do I. Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biol Pharm Bull. 2008 Jul;31(7):1392-6.

[iv] Bao HY, Zhang J, Yeo SJ, et al. Memory enhancing and neuroprotective effects of selected ginsenosides. Arch Pharm Res. 2005 Mar;28(3):335-42.

[v] Manna F, Abdel-Wahhab MA, Ahmed HH, Park MH. Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats. J Appl Toxicol. 2006 May-Jun;26(3):198-206.

[vi] Kim JH. Cardiovascular diseases and Panax ginseng: a review on molecular mechanisms and medical applications. J Ginseng Res. 2012;36:16-26.

[vii] Kim JH, Cho SY, Lee JH, et al. Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Res. 2007 Mar 9;1136(1):190-9.

[viii] Tomek SE, LaCrosse AL, Nemirovsky NE, et al. NMDA receptor modulators in the treatment of drug addiction. Pharmaceuticals (Basel). 2013;6(2):251-268.

[ix] Nah SY, Ki DH, Rhim H. Ginsenosides: Are any of them candidates for drugs acting on the central nervous system? CNS Drug Reviews. 2007;13(4):381-404.

[x] Joo SS, Yoo YM, Ahn BW, Nam SY, Kim YB, Hwang KW, Lee do I. Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biol Pharm Bull. 2008 Jul;31(7):1392-6.

[xi] Lee H, et al. Relationship. Between ginsenoside Rg3 and metabolic syndrome. Front Pharmacol. 2020;11:130.

[xii] Lombardo D, Kiselev MA. Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application. Pharmaceutics. 2022;14(3):543.

Copyright © 2023 James B. LaValle, Natural Formulations All rights reserved.

No part of this material may be used or reproduced in any manner whatsoever, stored in a retrieval system, or transmitted in any form, or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission of the author.

This material is provided for educational and informational purposes only to licensed health care professionals. This information is obtained from sources believed to be reliable, but its accuracy cannot be guaranteed. Herbs and other natural substances are very powerful and can occasionally cause dangerous allergic reactions in a small percentage of the population. Licensed health care professionals should rely on sound professional judgment when recommending herbs and natural medicines to specific individuals. Individual use of herbs and natural medicines should be supervised by an appropriate health care professional. The use of any specific product should always be in accordance with the manufacturer’s directions.

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Synapsin LPT™ by Mental Case is a naturally-derived nootropic designed to enhance cognitive functions, including focus, memory, and mental clarity, promoting optimal brain performance. Suitable for daily use.

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